2017 Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (pdf)

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Author Akihiko Yoshimura
Edition 1
Edition Year 2017
Format PDF
ISBN 9783319689289
Language English
Number Of Pages 268
Publisher Springer International Publishing

Description

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”.

Additional information

Author

Akihiko Yoshimura

Edition

1

Edition Year

2017

Format

PDF

ISBN

9783319689289

Language

English

Number Of Pages

268

Publisher

Springer International Publishing

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